Unknown

Dataset Information

0

Age-related aneuploidy through cohesion exhaustion.

ABSTRACT: The trend of women to become pregnant when older than in previous generations poses a paramount medical problem, for oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Recent data strongly suggest that as oocyte age increases sister chromatid cohesion is weakened or lost. Cohesin deterioration seems to contribute significantly to age-dependent aneuploidy, as discussed in this review.

SUBMITTER: Jessberger R 

PROVIDER: S-EPMC3367239 | biostudies-other | 2012 Jun

REPOSITORIES: biostudies-other

Json Xml

Similar Datasets

Unknown Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes.
| S-EPMC2939204 | biostudies-literature
Unknown Age-Related Loss of Cohesion: Causes and Effects.
| S-EPMC5536066 | biostudies-other
Unknown BAF180 promotes cohesion and prevents genome instability and aneuploidy.
| S-EPMC3988838 | biostudies-literature
Unknown Age Differences in Work Stress, Exhaustion, Well-Being, and Related Factors From an Ecological Perspective.
| S-EPMC6338997 | biostudies-literature
Unknown TICAM2-related pathway mediates neutrophil exhaustion.
| S-EPMC7463027 | biostudies-literature
Unknown Male breast cancer, age and sex chromosome aneuploidy.
| S-EPMC3590654 | biostudies-other
Unknown Increased LOH due to Defective Sister Chromatid Cohesion Is due Primarily to Chromosomal Aneuploidy and not Recombination.
| S-EPMC5633381 | biostudies-literature
Unknown Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes.
| S-EPMC6807363 | biostudies-literature
Unknown Moralized Health-Related Persuasion Undermines Social Cohesion.
| S-EPMC6005884 | biostudies-literature
Unknown The horse as a natural model to study reproductive aging-induced aneuploidy and weakened centromeric cohesion in oocytes.
| S-EPMC7695376 | biostudies-literature