Ontology highlight
ABSTRACT:
SUBMITTER: Hong JY
PROVIDER: S-EPMC3367828 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Hong Ji Yeon JY Park Jae-Il JI Lee Moonsup M Muñoz William A WA Miller Rachel K RK Ji Hong H Gu Dongmin D Ezan Jerome J Sokol Sergei Y SY McCrea Pierre D PD
Journal of cell science 20120201 Pt 3
The Wnt pathways contribute to many processes in cancer and development, with β-catenin being a key canonical component. p120-catenin, which is structurally similar to β-catenin, regulates the expression of certain Wnt target genes, relieving repression conferred by the POZ- and zinc-finger-domain-containing transcription factor Kaiso. We have identified the kinase Dyrk1A as a component of the p120-catenin-Kaiso trajectory of the Wnt pathway. Using rescue and other approaches in Xenopus laevis e ...[more]