Ontology highlight
ABSTRACT:
SUBMITTER: Rivenbark AG
PROVIDER: S-EPMC3368819 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Rivenbark Ashley G AG Stolzenburg Sabine S Beltran Adriana S AS Yuan Xinni X Rots Marianne G MG Strahl Brian D BD Blancafort Pilar P
Epigenetics 20120401 4
An obstacle in the treatment of human diseases such as cancer is the inability to selectively and effectively target historically undruggable targets such as transcription factors. Here, we employ a novel technology using artificial transcription factors (ATFs) to epigenetically target gene expression in cancer cells. We show that site-specific DNA methylation and long-term stable repression of the tumor suppressor Maspin and the oncogene SOX2 can be achieved in breast cancer cells via zinc-fing ...[more]