Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.
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ABSTRACT:
SUBMITTER: Majerus MA
PROVIDER: S-EPMC336910 | biostudies-other | 1992 Jun
REPOSITORIES: biostudies-other
Publications
Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.
Majérus M A MA Bibollet-Ruche F F Telliez J B JB Wasylyk B B Bailleul B B
Nucleic acids research 19920601 11
The ets-1 proto-oncogene codes for a transcription factor. In order to understand how ets-1 is regulated, we have cloned its promoter. We show that the promoter is inducible by serum and expression of c-Fos and c-Jun, and it is positively auto-regulated by its gene product. A 50 base-pair sequence is sufficient to confer c-Fos + c-Jun and c-Ets-1 responsiveness to a heterologous promoter. This element contains two AP1 and one Ets-1 like motifs. Striking, AP-1 and Ets-1 motifs are found in oncoge ...[more]
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