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"Clicked" sugar-curcumin conjugate: modulator of amyloid-? and tau peptide aggregation at ultralow concentrations.

ABSTRACT: The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-? and tau peptide aggregation is presented. Curcumin inhibits amyloid-? and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits A? and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.

SUBMITTER: Dolai S 

PROVIDER: S-EPMC3369720 | biostudies-other | 2011 Dec

REPOSITORIES: biostudies-other

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"Clicked" sugar-curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations.

Dolai Sukanta S   Shi Wei W   Corbo Christopher C   Sun Chong C   Averick Saadyah S   Obeysekera Dinali D   Farid Mina M   Alonso Alejandra A   Banerjee Probal P   Raja Krishnaswami K  

ACS chemical neuroscience 20111013 12

The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented. Curcumin inhibits amyloid-β and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Aβ and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more power  ...[more]