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BODIPY-based molecular probe for imaging of cerebral ?-amyloid plaques.

ABSTRACT: We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of ?-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic A? aggregates. ?-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of ?-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral ?-amyloid plaques in patients with Alzheimer's disease.

SUBMITTER: Ono M 

PROVIDER: S-EPMC3369805 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other

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BODIPY-based molecular probe for imaging of cerebral β-amyloid plaques.

Ono Masahiro M   Watanabe Hiroyuki H   Kimura Hiroyuki H   Saji Hideo H  

ACS chemical neuroscience 20120217 4

We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic Aβ aggregates. β-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of β-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral β-amyloid plaques in patients with Al  ...[more]