Ontology highlight
ABSTRACT:
SUBMITTER: Ono M
PROVIDER: S-EPMC3369805 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Ono Masahiro M Watanabe Hiroyuki H Kimura Hiroyuki H Saji Hideo H
ACS chemical neuroscience 20120217 4
We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic Aβ aggregates. β-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of β-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral β-amyloid plaques in patients with Al ...[more]