Ontology highlight
ABSTRACT:
SUBMITTER: Orlandi C
PROVIDER: S-EPMC3373406 | biostudies-other | 2012 Jun
REPOSITORIES: biostudies-other
Orlandi Cesare C Posokhova Ekaterina E Masuho Ikuo I Ray Thomas A TA Hasan Nazarul N Gregg Ronald G RG Martemyanov Kirill A KA
The Journal of cell biology 20120601 6
The extent and temporal characteristics of G protein-coupled receptor (GPCR) signaling are shaped by the regulator of G protein signaling (RGS) proteins, which promote G protein deactivation. With hundreds of GPCRs and dozens of RGS proteins, compartmentalization plays a key role in establishing signaling specificity. However, the molecular details and mechanisms of this process are poorly understood. In this paper, we report that the R7 group of RGS regulators is controlled by interaction with ...[more]