Ontology highlight
ABSTRACT:
SUBMITTER: Benjamini Y
PROVIDER: S-EPMC3378858 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Benjamini Yuval Y Speed Terence P TP
Nucleic acids research 20120209 10
GC content bias describes the dependence between fragment count (read coverage) and GC content found in Illumina sequencing data. This bias can dominate the signal of interest for analyses that focus on measuring fragment abundance within a genome, such as copy number estimation (DNA-seq). The bias is not consistent between samples; and there is no consensus as to the best methods to remove it in a single sample. We analyze regularities in the GC bias patterns, and find a compact description for ...[more]