Ontology highlight
ABSTRACT:
SUBMITTER: Chopra VS
PROVIDER: S-EPMC3386088 | biostudies-other | 2012 Jun
REPOSITORIES: biostudies-other
Chopra Vivek S VS Kong Nikki N Levine Michael M
Proceedings of the National Academy of Sciences of the United States of America 20120529 24
Transcriptional repressors are thought to inhibit gene expression by interfering with the binding or function of RNA Polymerase II, perhaps by promoting local chromatin condensation. Here, we present evidence for a distinctive mechanism of repression, whereby sequence-specific repressors prevent the looping of distal enhancers to the promoter. Particular efforts focus on the Snail repressor, which plays a conserved role in promoting epithelial-mesenchyme transitions in both invertebrates and ver ...[more]