Ontology highlight
ABSTRACT:
SUBMITTER: Gupta S
PROVIDER: S-EPMC3386804 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Gupta Shipra S Thornley Thomas B TB Gao Wenda W Larocca Rafael R Turka Laurence A LA Kuchroo Vijay K VK Strom Terry B TB
The Journal of clinical investigation 20120611 7
Tregs play a pivotal role in inducing and maintaining donor-specific transplant tolerance. The T cell immunoglobulin and mucin domain-3 protein (TIM-3) is expressed on many fully activated effector T cells. Along with program death 1 (PD-1), TIM-3 is used as a marker for exhausted effector T cells, and interaction with its ligand, galectin-9, leads to selective death of TIM-3+ cells. We report herein the presence of a galectin-9-sensitive CD4+FoxP3+TIM-3+ population of T cells, which arose from ...[more]