Ontology highlight
ABSTRACT:
SUBMITTER: Bellucci R
PROVIDER: S-EPMC3386806 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Bellucci Roberto R Nguyen Hong-Nam HN Martin Allison A Heinrichs Stefan S Schinzel Anna C AC Hahn William C WC Ritz Jerome J
The Journal of clinical investigation 20120611 7
Natural killer (NK) cells are primary effectors of innate immunity directed against transformed tumor cells. In response, tumor cells have developed mechanisms to evade NK cell-mediated lysis through molecular mechanisms that are not well understood. In the present study, we used a lentiviral shRNA library targeting more than 1,000 human genes to identify 83 genes that promote target cell resistance to human NK cell-mediated killing. Many of the genes identified in this genetic screen belong to ...[more]