Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
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ABSTRACT:
SUBMITTER: Masuoka M
PROVIDER: S-EPMC3386810 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Publications
Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
Masuoka Miho M Shiraishi Hiroshi H Ohta Shoichiro S Suzuki Shoichi S Arima Kazuhiko K Aoki Shigehisa S Toda Shuji S Inagaki Naoki N Kurihara Yuichi Y Hayashida Sayaka S Takeuchi Satoshi S Koike Kenta K Ono Junya J Noshiro Hirokazu H Furue Masutaka M Conway Simon J SJ Narisawa Yutaka Y Izuhara Kenji K
The Journal of clinical investigation 20120611 7
Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The mechanisms underlying chronicity in allergic inflammation remain unresolved. Periostin, a recently characterized matricellular protein, interacts with several cell surface integrin molecules, providing signals for tissue development and remodeling. Here we show that periostin is a critical mediator for the amplification ...[more]
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