Ontology highlight
ABSTRACT:
SUBMITTER: Jeon YJ
PROVIDER: S-EPMC3386819 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Jeon Young Joo YJ Jo Mi Gyeong MG Yoo Hee Min HM Hong Se-Hoon SH Park Jung-Mi JM Ka Seung Hyeun SH Oh Kyu Hee KH Seol Jae Hong JH Jung Yong Keun YK Chung Chin Ha CH
The Journal of clinical investigation 20120618 7
Identification of the cellular mechanisms that mediate cancer cell chemosensitivity is important for developing new cancer treatment strategies. Several chemotherapeutic drugs increase levels of the posttranslational modifier ISG15, which suggests that ISGylation could suppress oncogenesis. However, how ISGylation of specific target proteins controls tumorigenesis is unknown. Here, we identified proteins that are ISGylated in response to chemotherapy. Treatment of a human mammary epithelial cell ...[more]