Ontology highlight
ABSTRACT:
SUBMITTER: Miyazaki T
PROVIDER: S-EPMC3387818 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Miyazaki Tomoyuki T Takase Kenkichi K Nakajima Waki W Tada Hirobumi H Ohya Daisuke D Sano Akane A Goto Takahisa T Hirase Hajime H Malinow Roberto R Takahashi Takuya T
The Journal of clinical investigation 20120618 7
Stressful events during early childhood can have a profound lifelong influence on emotional and cognitive behaviors. However, the mechanisms by which stress affects neonatal brain circuit formation are poorly understood. Here, we show that neonatal social isolation disrupts molecular, cellular, and circuit developmental processes, leading to behavioral dysfunction. Neonatal isolation prevented long-term potentiation and experience-dependent synaptic trafficking of α-amino-3-hydroxy-5-methylisoxa ...[more]