Ontology highlight
ABSTRACT:
SUBMITTER: Ciupe SM
PROVIDER: S-EPMC3388102 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Ciupe Stanca M SM Hews Sarah S
PloS one 20120702 7
We develop mathematical models for the role of hepatitis B e-antigen in creating immunological tolerance during hepatitis B virus infection and propose mechanisms for hepatitis B e-antigen clearance, subsequent emergence of a potent cellular immune response, and the effect of these on liver damage. We investigate the dynamics of virus-immune cells interactions, and derive parameter regimes that allow for viral persistence. We modify the model to account for mechanisms responsible for hepatitis B ...[more]