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Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids.

ABSTRACT: By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl.

SUBMITTER: Wang H

PROVIDER: S-EPMC3388862 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids.

Wang Han H Wen Kun K Nurahmat Nurbiya N Shao Yan Y Zhang He H Wei Chao C Li Ya Y Shen Yongjia Y Sun Zhihua Z

Beilstein journal of organic chemistry 20120516

By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl. ...[more]

PMID: 23015822

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