Ontology highlight
ABSTRACT:
SUBMITTER: Oguri H
PROVIDER: S-EPMC3388883 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Oguri Hiroki H Mizoguchi Haruki H Oikawa Hideaki H Ishiyama Aki A Iwatsuki Masato M Otoguro Kazuhiko K Omura Satoshi S
Beilstein journal of organic chemistry 20120622
By emulating the universal biosynthetic strategy, which employs modular assembly and divergent cyclizations, we have developed a four-step synthetic process to yield a collection of natural-product-inspired scaffolds. Modular assembly of building blocks onto a piperidine-based manifold 6, having a carboxylic acid group, was achieved through Ugi condensation, N-acetoacetylation and diazotransfer, leading to cyclization precursors. The rhodium-catalyzed tandem cyclization and divergent cycloadditi ...[more]