Ontology highlight
ABSTRACT:
SUBMITTER: Chamberlain JS
PROVIDER: S-EPMC339001 | biostudies-other | 1988 Dec
REPOSITORIES: biostudies-other
Chamberlain J S JS Gibbs R A RA Ranier J E JE Nguyen P N PN Caskey C T CT
Nucleic acids research 19881201 23
The application of recombinant DNA technology to prenatal diagnosis of many recessively inherited X-linked diseases is complicated by a high frequency of heterogeneous, new mutations (1). Partial gene deletions account for more than 50% of Duchenne muscular dystrophy (DMD) lesions, and approximately one-third of all cases result from a new mutation (2-5). We report the isolation and DNA sequence of several deletion prone exons from the human DMD gene. We also describe a rapid method capable of d ...[more]