Ontology highlight
ABSTRACT:
SUBMITTER: Lorts A
PROVIDER: S-EPMC3390853 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Lorts Angela A Schwanekamp Jennifer A JA Baudino Troy A TA McNally Elizabeth M EM Molkentin Jeffery D JD
Proceedings of the National Academy of Sciences of the United States of America 20120618 27
The muscular dystrophies are broadly classified as muscle wasting diseases with myofiber dropout due to cellular necrosis, inflammation, alterations in extracellular matrix composition, and fatty cell replacement. These events transpire and progress despite ongoing myofiber regeneration from endogenous satellite cells. The degeneration/regeneration response to muscle injury/disease is modulated by the proinflammatory cytokine transforming growth factor-β (TGF-β), which can also profoundly influe ...[more]