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Na?Co?(AsO?)(As?O?): a new sodium cobalt arsenate.

ABSTRACT: In the title compound, tris-odium dicobalt arsenate diarsenate, Na?Co?AsO?As?O?, the two Co atoms, one of the two As and three of the seven O atoms lie on special positions, with site symmetries 2 and m for the Co, m for the As, and 2 and twice m for the O atoms. The two Na atoms are disordered over two general and special positions [occupancies 0.72?(3):0.28?(3) and 0.940?(6):0.060?(6), respectively]. The main structural feature is the association of the CoO? octa-hedra in the ab plane, forming Co?O?? units, which are corner- and edge-connected via AsO? and As?O? arsenate groups, giving rise to a complex polyhedral connectivity with small tunnels, such as those running along the b- and c-axis directions, in which the Na? ions reside. The structural model is validated by both bond-valence-sum and charge-distribution methods, and the distortion of the coordination polyhedra is analyzed by means of the effective coordination number.

SUBMITTER: Guesmi A

PROVIDER: S-EPMC3393142 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other

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Na₃Co₂(AsO₄)(As₂O₇): a new sodium cobalt arsenate.

Guesmi Abderrahmen A Driss Ahmed A

Acta crystallographica. Section E, Structure reports online 20120627 Pt 7

In the title compound, tris-odium dicobalt arsenate diarsenate, Na₃Co₂AsO₄As₂O₇, the two Co atoms, one of the two As and three of the seven O atoms lie on special positions, with site symmetries 2 and m for the Co, m for the As, and 2 and twice m for the O atoms. The two Na atoms are disordered over two general and special positions [occupancies 0.72 (3):0.28 (3) and 0.940 (6):0.060 (6), respectively]. The main structural feature is the association of the CoO₆ octa-hedra in the ab plane, forming ...[more]

PMID: 22807699

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Project description:AimsEmipagliflozin (EMPA) is a potent inhibitor of the renal sodium-glucose co-transporter 2 (SGLT2) and an effective treatment for type-2 diabetes. In patients with diabetes and heart failure, EMPA has cardioprotective effects independent of improved glycaemic control, despite SGLT2 not being expressed in the heart. A number of non-canonical mechanisms have been proposed to explain these cardiac effects, most notably an inhibitory action on cardiac Na+/H+ exchanger 1 (NHE1), causing a reduction in intracellular [Na+] ([Na+]i). However, at resting intracellular pH (pHi), NHE1 activity is very low and its pharmacological inhibition is not expected to meaningfully alter steady-state [Na+]i. We re-evaluate this putative EMPA target by measuring cardiac NHE1 activity.Methods and resultsThe effect of EMPA on NHE1 activity was tested in isolated rat ventricular cardiomyocytes from measurements of pHi recovery following an ammonium pre-pulse manoeuvre, using cSNARF1 fluorescence imaging. Whereas 10 µM cariporide produced near-complete inhibition, there was no evidence for NHE1 inhibition with EMPA treatment (1, 3, 10, or 30 µM). Intracellular acidification by acetate-superfusion evoked NHE1 activity and raised [Na+]i, reported by sodium binding benzofuran isophthalate (SBFI) fluorescence, but EMPA did not ablate this rise. EMPA (10 µM) also had no significant effect on the rate of cytoplasmic [Na+]i rise upon superfusion of Na+-depleted cells with Na+-containing buffers. In Langendorff-perfused mouse, rat and guinea pig hearts, EMPA did not affect [Na+]i at baseline nor pHi recovery following acute acidosis, as measured by 23Na triple quantum filtered NMR and 31P NMR, respectively.ConclusionsOur findings indicate that cardiac NHE1 activity is not inhibited by EMPA (or other SGLT2i's) and EMPA has no effect on [Na+]i over a wide range of concentrations, including the therapeutic dose. Thus, the beneficial effects of SGLT2i's in failing hearts should not be interpreted in terms of actions on myocardial NHE1 or intracellular [Na+].

Dataset Information

Na?Co?(AsO?)(As?O?): a new sodium cobalt arsenate.

Publications

Na₃Co₂(AsO₄)(As₂O₇): a new sodium cobalt arsenate.

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