Ontology highlight
ABSTRACT:
SUBMITTER: Meehan M
PROVIDER: S-EPMC3395855 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Meehan Maria M Parthasarathi Laavanya L Moran Niamh N Jefferies Caroline A CA Foley Niamh N Lazzari Elisa E Murphy Derek D Ryan Jacqueline J Ortiz Berenice B Fabius Armida W M AW Chan Timothy A TA Stallings Raymond L RL
Molecular cancer 20120205
<h4>Background</h4>Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. The molecular mechanism, however, by which PTPRD renders ...[more]