Ontology highlight
ABSTRACT:
SUBMITTER: Mayer S
PROVIDER: S-EPMC3397873 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Mayer Sandra S Roeser Marc M Lachmann Peter P Ishii Sumiyashi S Suh Jae Mi JM Harlander Sabine S Desch Michael M Brunssen Coy C Morawietz Henning H Tsai Sophia Y SY Tsai Ming-Jer MJ Hohenstein Bernd B Hugo Christian C Todorov Vladimir T VT
The Journal of biological chemistry 20120529 29
This study aimed to investigate the possible involvement of the orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) in the regulation of renin gene expression. COUP-TFII colocalized with renin in the juxtaglomerular cells of the kidney, which are the main source of renin in vivo. Protein-DNA binding studies demonstrated that COUP-TFII binds to an imperfect direct repeat COUP-TFII recognition sequence (termed hereafter proxDR) in the proximal renin prom ...[more]