Differential regulation of embryonic and adult ? cell replication.

ABSTRACT: Diabetes results from an inadequate functional ? cell mass, either due to autoimmune destruction (Type 1 diabetes) or insulin resistance combined with ? cell failure (Type 2 diabetes). Strategies to enhance ? cell regeneration or increase cell proliferation could improve outcomes for patients with diabetes. Research conducted over the past several years has revealed that factors regulating embryonic ? cell mass expansion differ from those regulating replication of ? cells post-weaning. This article aims to compare and contrast factors known to control embryonic and postnatal ? cell replication. In addition, we explore the possibility that connective tissue growth factor (CTGF) could increase adult ? cell replication. We have already shown that CTGF is required for embryonic ? cell proliferation and is sufficient to induce replication of embryonic ? cells. Here we examine whether adult ? cell replication and expansion of ? cell mass can be enhanced by increased CTGF expression in mature ? cells.

SUBMITTER: Gunasekaran U 

PROVIDER: S-EPMC3404874 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other