Ontology highlight
ABSTRACT:
SUBMITTER: Schoenebeck JJ
PROVIDER: S-EPMC3410846 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Schoenebeck Jeffrey J JJ Hutchinson Sarah A SA Byers Alexandra A Beale Holly C HC Carrington Blake B Faden Daniel L DL Rimbault Maud M Decker Brennan B Kidd Jeffrey M JM Sood Raman R Boyko Adam R AR Fondon John W JW Wayne Robert K RK Bustamante Carlos D CD Ciruna Brian B Ostrander Elaine A EA
PLoS genetics 20120802 8
Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our d ...[more]