Ontology highlight
ABSTRACT:
SUBMITTER: Ishibashi K
PROVIDER: S-EPMC3418313 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Molecular biology of the cell 20120627 16
Autophagy is a bulk degradation system in all eukaryotic cells and regulates a variety of biological activities in higher eukaryotes. Recently involvement of autophagy in the regulation of the secretory pathway has also been reported, but the molecular mechanism linking autophagy with the secretory pathway remains largely unknown. Here we show that Atg16L1, an essential protein for canonical autophagy, is localized on hormone-containing dense-core vesicles in neuroendocrine PC12 cells and that k ...[more]