Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3423784 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Liu Yong Y Deng Jiehui J Wang Lin L Lee Heehyoung H Armstrong Brian B Scuto Anna A Kowolik Claudia C Weiss Lawrence M LM Forman Stephen S Yu Hua H
Blood 20120628 7
STAT3 plays a crucial role in promoting progression of human cancers, including several types of B-cell lymphoma. However, as a transcription factor lacking its own enzymatic activity, STAT3 remains difficult to target with small-molecule drugs in the clinic. Here we demonstrate that persistent activated STAT3 colocalizes with elevated expression of S1PR1, a G-protein-coupled receptor for sphingosine-1-phosphate (S1P), in the tumor cells of the activated B cell-like subtype of diffuse large B-ce ...[more]