Ontology highlight
ABSTRACT:
SUBMITTER: Dridi S
PROVIDER: S-EPMC3427082 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Dridi Sami S Hirano Yoshio Y Tarallo Valeria V Kim Younghee Y Fowler Benjamin J BJ Ambati Balamurali K BK Bogdanovich Sasha S Chiodo Vince A VA Hauswirth William W WW Kugel Jennifer F JF Goodrich James A JA Ponicsan Steven L SL Hinton David R DR Kleinman Mark E ME Baffi Judit Z JZ Gelfand Bradley D BD Ambati Jayakrishna J
Proceedings of the National Academy of Sciences of the United States of America 20120806 34
Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in geographic atrophy (GA), a late stage of age-related macular degeneration that causes blindness in millions of people worldwide. Here we show increased extracellular-signal-regulated kinase (ERK) 1/2 phosphorylation in the RPE of human eyes with GA and that RPE degeneration in mouse eyes and in human cell culture indu ...[more]