Ontology highlight
ABSTRACT:
SUBMITTER: Seybold BA
PROVIDER: S-EPMC3427089 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Seybold Bryan A BA Stanco Amelia A Cho Kathleen K A KK Potter Gregory B GB Kim Carol C Sohal Vikaas S VS Rubenstein John L R JL Schreiner Christoph E CE
Proceedings of the National Academy of Sciences of the United States of America 20120702 34
Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry on auditory cortical responses are unknown. We ablated ~30% of dendrite-targeting cortical inhibitory interneurons after the critical period by studying mice with a conditional dele ...[more]