Ontology highlight
ABSTRACT:
SUBMITTER: Chen HJ
PROVIDER: S-EPMC3428084 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Chen Huanhuan Joyce HJ Edwards Robert R Tucci Serena S Bu Pengcheng P Milsom Jeff J Lee Sang S Edelmann Winfried W Gümüs Zeynep H ZH Shen Xiling X Lipkin Steven S
The Journal of clinical investigation 20120806 9
Chemotactic cytokines (chemokines) can help regulate tumor cell invasion and metastasis. Here, we show that chemokine 25 (CCL25) and its cognate receptor chemokine receptor 9 (CCR9) inhibit colorectal cancer (CRC) invasion and metastasis. We found that CCR9 protein expression levels were highest in colon adenomas and progressively decreased in invasive and metastatic CRCs. CCR9 was expressed in both primary tumor cell cultures and colon-cancer-initiating cell (CCIC) lines derived from early-stag ...[more]