Ontology highlight
ABSTRACT:
SUBMITTER: Zabala AO
PROVIDER: S-EPMC3428717 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Zabala Angelica O AO Xu Wei W Chooi Yit-Heng YH Tang Yi Y
Chemistry & biology 20120801 8
Azaphilones are a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities. Although widespread among various fungi, their biosynthesis has not been thoroughly elucidated. By activation of a silent (aza) gene cluster in Aspergillus niger ATCC 1015, we discovered six azaphilone compounds, azanigerones A-F (1, 3-7). Transcriptional analysis and deletion of a key polyketide synthase (PKS) gene further confirmed the i ...[more]