Ontology highlight
ABSTRACT:
SUBMITTER: de Goer de Herve MG
PROVIDER: S-EPMC3432473 | biostudies-other | 2012
REPOSITORIES: biostudies-other
de Goër de Herve M G MG Jaafoura S S Vallée M M Taoufik Y Y
Nature communications 20120101
During the primary immune response, CD8 memory emerges from an environment of strong immune activation. The FoxP3(+) regulatory CD4 T-cell subset (Treg) is known as a key suppressive component of the immune system. Here we report that Tregs are required for the generation of functional CD8 memory. In the absence of Tregs during priming, the resulting memory cells proliferate poorly and fail to differentiate into functional cytotoxic secondary effectors following antigen reactivation. We find tha ...[more]