Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.
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ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC3432796 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Publications
Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.
Sun Jingru J Liu Yiyong Y Aballay Alejandro A
EMBO reports 20120713 9
The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1--a G protein-coupled catecholamine receptor expressed in neurons--suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during dev ...[more]
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