Mechanisms of thyroid hormone action.
Ontology highlight
ABSTRACT:
SUBMITTER: Brent GA
PROVIDER: S-EPMC3433956 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Publications
Mechanisms of thyroid hormone action.
The Journal of clinical investigation 20120904 9
Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including profound mental retardation, obesity, metabolic disorders, and a number of cancers. The mechanism of thyroid hormone action has been informed by these clinical observations as well as by animal models and has influenced the way we view the role of local ligand availability; tissue a ...[more]
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