Functional dosimetric metrics for predicting radiation-induced lung injury in non-small cell lung cancer patients treated with chemoradiotherapy.

ABSTRACT: BACKGROUND: Radiation-induced lung injury (RILI) is an important dose-limiting toxicity during thoracic radiotherapy. The purpose of this study is to investigate single photon emission computed tomography (SPECT) perfusion-weighted functional dose-volume histogram (FDVH) for predicting RILI in non-small cell lung cancer (NSCLC) patients treated with definitive chemoradiotherapy. METHODS: Fifty-seven locally advanced NSCLC patients receiving chemoradiotherapy were enrolled prospectively. Patients had treatment scans and dose calculations to provide a standard dose-volume histogram (DVH). Fusion of SPECT and computed tomography scans provided perfusion-weighted FDVH and associated functional dosimetric parameters (relative volumes of functional lung receiving more than a threshold dose of 5 - 60?Gy at increments of 5?Gy [FV5 - FV60]). The predictive abilities of FDVH and DVH were calculated and compared based on the area under receiver operating characteristic (ROC) curve (AUC). RESULTS: The accumulative incidence of? ?? 2 grade RILI was 19.3% with a median follow-up of 12?months. Univariate analysis showed that the functional (FV5 - FV60) and standard (V5 - V40) parameters were associated with RILI (all value of p?

SUBMITTER: Wang D 

PROVIDER: S-EPMC3434088 | biostudies-other | 2012

REPOSITORIES: biostudies-other