Ontology highlight
ABSTRACT:
SUBMITTER: Vielle A
PROVIDER: S-EPMC3441679 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Vielle Anne A Lang Jackie J Dong Yan Y Ercan Sevinc S Kotwaliwale Chitra C Rechtsteiner Andreas A Appert Alex A Chen Q Brent QB Dose Andrea A Egelhofer Thea T Kimura Hiroshi H Stempor Przemyslaw P Dernburg Abby A Lieb Jason D JD Strome Susan S Ahringer Julie J
PLoS genetics 20120913 9
The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits form a complex homologous to condensin. The mechanism by which the DCC downregulates gene expression remains unclear. Here we show that the DCC controls the methylation state of lysine 20 of histone H4, ...[more]