Ontology highlight
ABSTRACT:
SUBMITTER: Bertero T
PROVIDER: S-EPMC3441733 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Bertero Thomas T Grosso Sébastien S Robbe-Sermesant Karine K Lebrigand Kevin K Hénaoui Imene-Sarah IS Puisségur Marie-Pierre MP Fourre Sandra S Zaragosi Laure-Emmanuelle LE Mazure Nathalie M NM Ponzio Gilles G Cardinaud Bruno B Barbry Pascal P Rezzonico Roger R Mari Bernard B
PloS one 20120913 9
Specificity of interaction between a microRNA (miRNA) and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b and hsa-miR-210, though triggered by different stimuli (i.e. lipopolysaccharides and h ...[more]