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IS6110-mediated deletion polymorphism in isogenic strains of Mycobacterium tuberculosis.

ABSTRACT: Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study provides the first description of an IS6110-mediated deletion event in truly isogenic strains. We also provide further support for the hypothesis that the region from Rv1754 to Rv1765 is a hot spot for IS6110 insertion and deletion events.

SUBMITTER: Sampson SL 

PROVIDER: S-EPMC344511 | biostudies-other | 2004 Feb

REPOSITORIES: biostudies-other

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