Ontology highlight
ABSTRACT:
SUBMITTER: Carmichael CL
PROVIDER: S-EPMC3458381 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Carmichael Catherine L CL Metcalf Donald D Henley Katya J KJ Kruse Elizabeth A EA Di Rago Ladina L Mifsud Sandra S Alexander Warren S WS Kile Benjamin T BT
Proceedings of the National Academy of Sciences of the United States of America 20120830 38
The transcription factor encoded by the E-twenty-six (ETS)-related gene, ERG, is an essential regulator of hematopoietic stem cell function and a potent human oncoprotein. Enforced expression of ERG in murine hematopoietic cells leads to the development of a well-characterized lymphoid leukemia and a less well-defined non lymphoid disease. To clarify the latter, we generated murine bone marrow chimeras with enforced Erg expression in engrafted hematopoietic progenitor cells. As expected, these m ...[more]