Ontology highlight
ABSTRACT:
SUBMITTER: Miller B
PROVIDER: S-EPMC3458725 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Beilstein journal of organic chemistry 20120713
Hydrozirconation of 1-hexyne, the addition to in situ prepared N-acyliminium species, and ring-closing metathesis (RCM) were key steps in the preparation of a tricyclic isoindolinone scaffold. An unusual alkene isomerization process during the RCM was identified and studied in some detail. Chemical diversification for library synthesis was achieved by a subsequent alkene epoxidation and zinc-mediated aminolysis reaction. The resulting library products provided selective hits among a large number ...[more]