Corruption and spread of pathogenic proteins in neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Walker LC
PROVIDER: S-EPMC3460416 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Publications
Corruption and spread of pathogenic proteins in neurodegenerative diseases.
Walker Lary C LC LeVine Harry H
The Journal of biological chemistry 20120809 40
With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is structurally corrupted by its misfolded conformer. The latest research indicates that, once formed, proteopathic seeds can spread from one locale to another via cellular uptake, transport, and release. ...[more]
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