Ontology highlight
ABSTRACT:
SUBMITTER: Sharan S
PROVIDER: S-EPMC3463825 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Sharan Satish S Iwuchukwu Otito F OF Canney Daniel J DJ Zimmerman Cheryl L CL Nagar Swati S
Drug metabolism and disposition: the biological fate of chemicals 20120717 10
Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested that the kinetics of preformed and in vivo-formed metabolites are comparable. This subject has been a topic of debate. We have compared the kinetics of in vivo-formed with preformed metabolites. trans-3,5,4'-Trihydroxystilbene [trans-resveratrol (RES)] and its two major metabolites, resveratrol-3-sulfate (R3S) and resveratrol-3-glucuronide (R3G) were used as model substrates. The pharmacokin ...[more]