Neurovascular uncoupling under mild hypoxic hypoxia: an EEG-fMRI study in rats.
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ABSTRACT:
SUBMITTER: Sumiyoshi A
PROVIDER: S-EPMC3463877 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Publications
Neurovascular uncoupling under mild hypoxic hypoxia: an EEG-fMRI study in rats.
Sumiyoshi Akira A Suzuki Hideaki H Shimokawa Hiroaki H Kawashima Ryuta R
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120725 10
The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation=83.6±12.1%) induced significant reductions in fMRI responses (P<0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen s ...[more]
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