Ontology highlight
ABSTRACT:
SUBMITTER: Cao R
PROVIDER: S-EPMC3465417 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Cao Renhai R Ji Hong H Feng Ninghan N Zhang Yin Y Yang Xiaojuan X Andersson Patrik P Sun Yuping Y Tritsaris Katerina K Hansen Anker Jon AJ Dissing Steen S Cao Yihai Y
Proceedings of the National Academy of Sciences of the United States of America 20120911 39
Interplay between various lymphangiogenic factors in promoting lymphangiogenesis and lymphatic metastasis remains poorly understood. Here we show that FGF-2 and VEGF-C, two lymphangiogenic factors, collaboratively promote angiogenesis and lymphangiogenesis in the tumor microenvironment, leading to widespread pulmonary and lymph-node metastases. Coimplantation of dual factors in the mouse cornea resulted in additive angiogenesis and lymphangiogenesis. At the molecular level, we showed that FGFR-1 ...[more]