Ontology highlight
ABSTRACT:
SUBMITTER: Holt JE
PROVIDER: S-EPMC3469513 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Holt Janet E JE Lane Simon I R SI Jennings Phoebe P García-Higuera Irene I Moreno Sergio S Jones Keith T KT
Molecular biology of the cell 20120823 20
FZR1 is an anaphase-promoting complex (APC) activator best known for its role in the mitotic cell cycle at M-phase exit, in G1, and in maintaining genome integrity. Previous studies also established that it prevents meiotic resumption, equivalent to the G2/M transition. Here we report that mouse oocytes lacking FZR1 undergo passage through meiosis I that is accelerated by ~1 h, and this is due to an earlier onset of spindle assembly checkpoint (SAC) satisfaction and APC(CDC20) activity. However, ...[more]