Ontology highlight
ABSTRACT:
SUBMITTER: Nowsheen S
PROVIDER: S-EPMC3469581 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Nowsheen Somaira S Cooper Tiffiny T Stanley Jennifer A JA Yang Eddy S ES
PloS one 20121011 10
Few therapeutic options exist for the highly aggressive triple negative breast cancers (TNBCs). In this study, we report that a contextual synthetic lethality can be achieved both in vitro and in vivo with combined EGFR and PARP inhibition with lapatinib and ABT-888, respectively. The mechanism involves a transient DNA double strand break repair deficit induced by lapatinib and subsequent activation of the intrinsic pathway of apoptosis. Further dissection of the mechanism reveals that EGFR and ...[more]