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Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma.

ABSTRACT: To determine risk factors associated with recurrence in patients with high intermediate risk (HIR) endometrioid adenocarcinoma.A retrospective analysis of patients with HIR endometrioid adenocarcinoma who underwent hysterectomy, bilateral salpingo-oophorectomy, with or without pelvic/para-aortic lymphadenectomy at the University of Pennsylvania between 1990 and 2009 was performed.A total of 103 women with HIR endometrial cancer were identified. Multivariable analysis revealed that ?2/3 myometrial invasion (HR, 4.79; p=0.010) and grade 3 disease (HR, 3.04; p=0.045) were independently predictive of distant metastases. The 5-year distant metastases free survival (DMFS) for patients with neither or one of these risk factors was 89%, and the 5-year DMFS for patients with both risk factors was 48% (p<0.001).Patients with both grade 3 disease and deep third myometrial invasion have a high risk of distant metastases. Identifying these patients may be important in rationally selecting patients for systemic therapy.

SUBMITTER: Bahng AY 

PROVIDER: S-EPMC3469861 | biostudies-other | 2012 Oct

REPOSITORIES: biostudies-other

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Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma.

Bahng Agnes Y AY   Chu Christina C   Wileyto Paul P   Rubin Stephen S   Lin Lilie L LL  

Journal of gynecologic oncology 20120919 4

<h4>Objective</h4>To determine risk factors associated with recurrence in patients with high intermediate risk (HIR) endometrioid adenocarcinoma.<h4>Methods</h4>A retrospective analysis of patients with HIR endometrioid adenocarcinoma who underwent hysterectomy, bilateral salpingo-oophorectomy, with or without pelvic/para-aortic lymphadenectomy at the University of Pennsylvania between 1990 and 2009 was performed.<h4>Results</h4>A total of 103 women with HIR endometrial cancer were identified. M  ...[more]

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