Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3476542 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Li Xiaojuan X Zhong Hui H Bao Weili W Boulad Nayla N Evangelista Jessie J Haider Muhammad Anis MA Bussel James J Yazdanbakhsh Karina K
Blood 20120802 16
B lymphocytes producing antiplatelet autoantibodies play a major role in autoimmune thrombocytopenia (ITP). However, certain B cells, including the human CD19(+)CD24(hi)CD38(hi) subpopulation, possess regulatory functions mediated partly by IL-10. In a cohort of chronic ITP patients with low platelet counts who consisted of patients off treatment, we found a lower frequency of CD19(+)CD24(hi)CD38(hi) in the peripheral compartment of nonsplenectomized patients (P = .03). IL-10 expression after ac ...[more]