Ontology highlight
ABSTRACT:
SUBMITTER: Sato T
PROVIDER: S-EPMC3479468 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Sato Takuya T Yokonishi Tetsuhiro T Komeya Mitsuru M Katagiri Kumiko K Kubota Yoshinobu Y Matoba Shogo S Ogonuki Narumi N Ogura Atsuo A Yoshida Shosei S Ogawa Takehiko T
Proceedings of the National Academy of Sciences of the United States of America 20120910 42
Male infertility is most commonly caused by spermatogenic defects or insufficiencies, the majority of which are as yet cureless. Recently, we succeeded in cultivating mouse testicular tissues for producing fertile sperm from spermatogonial stem cells. Here, we show that one of the most severe types of spermatogenic defect mutant can be treated by the culture method without any genetic manipulations. The Sl/Sl(d) mouse is used as a model of such male infertility. The testis of the Sl/Sl(d) mouse ...[more]