Ontology highlight
ABSTRACT:
SUBMITTER: Suraweera A
PROVIDER: S-EPMC3482661 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Suraweera Amila A Münch Christian C Hanssum Ariane A Bertolotti Anne A
Molecular cell 20120906 2
The ubiquitin-proteasome system targets many cellular proteins for degradation and thereby controls most cellular processes. Although it is well established that proteasome inhibition is lethal, the underlying mechanism is unknown. Here, we show that proteasome inhibition results in a lethal amino acid shortage. In yeast, mammalian cells, and flies, the deleterious consequences of proteasome inhibition are rescued by amino acid supplementation. In all three systems, this rescuing effect occurs w ...[more]