Targeting oncogenic Ras signaling in hematologic malignancies.
Ontology highlight
ABSTRACT:
SUBMITTER: Ward AF
PROVIDER: S-EPMC3482854 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Publications
Targeting oncogenic Ras signaling in hematologic malignancies.
Ward Ashley F AF Braun Benjamin S BS Shannon Kevin M KM
Blood 20120816 17
Ras proteins are critical nodes in cellular signaling that integrate inputs from activated cell surface receptors and other stimuli to modulate cell fate through a complex network of effector pathways. Oncogenic RAS mutations are found in ∼25% of human cancers and are highly prevalent in hematopoietic malignancies. Because of their structural and biochemical properties, oncogenic Ras proteins are exceedingly difficult targets for rational drug discovery, and no mechanism-based therapies exist fo ...[more]
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